Pallavi Shukla Srabani Mukherjee


Genes encoding subunits forming SWI/SNF chromatin remodeling complex have been found to inhibit malignant transformation and progression. ARID1A is one such subunit and inactivating mutations in ARID1A gene encoding ARID1A are found in wide spectrum of cancer and most frequently in gynecologic cancer as in ovarian clear cell adenocarcinoma, ovarian endometrioid adenocarcinoma and uterine endometrioid adenocarcinoma. Many reports suggest that ARID1A play a tumour suppressive role in these cancers. This review focuses on tumour suppressive role of ARID1A, its synthetic lethal partners and emerging therapies in ARID1A mutated ovarian and endometrial carcinoma.