The Indian Collaborative Research on Wilson’s Disease (ICROWD) is a multi-institutional research effort to understand the clinical and molecular characteristics of Wilson’s disease, a prevalent Mendelian genetic disease globally. The initiative fills in the gap of systematic understanding of the genetic epidemiology and genotype phenotype correlations in Wilson’s Disease. Through a pan-Indian collaborative network, the initiative provides clinical workup, molecular characterization and key insights into the disease pathophysiology and progression. This article describes the premise, and provides an overview of the research initiated through the ICROWD and the salient features of the research collaboration. Going forward the ICROWD initiative aims to extend into understanding molecular pathology as well as modeling the disease process towards insights into novel therapeutics including genome editing.