Insulin Autoimmune Syndrome (Hirata Disease): A Rare Case Report in an Indian Patient

Abstract

An unusual cause of spontaneous hypoglycemia is Insulin Autoimmune Syndrome (IAS) or Hirata Disease, characterized by high levels of insulinemia and circulating autoantibodies to insulin in subjects without prior insulin administration. Till 2009, more than 200 cases from Japan and as many as 60 cases in Caucasians and 20 cases in East Asians have been reported. To the best of our knowledge, this is the second case of IAS reported from India.