Population-scale genome programmes in many countries which were not covered in the global programmes offer new opportunities to uncover genetic variability and candidate genes and variants associated with genetic diseases. In many ways, the data provides a unique view of the genetic epidemiology of diseases and traits and evidence to enable cost-effective screening and prevention of genetic diseases, apart from generating evidence to support policies. The recent genomics initiatives from Qatar, including the Qatar Genome Programme becomes important in this respect. This commentary provides an overview of the genomic data from Qatar and insights that have come out of the data addressing pertinent questions on ancestry, admixture and landscape of genetic diseases and traits. We also provide a view of how the ambitious genome programme in the country could potentially translate to better understanding of genetic diseases and impacting healthcare.