Prostate cancer is the 2ndcommonest malignancy in men worldwide. It is, however, the commonest in Nigeria. While several disparities have been documented between Caucasian men and men of African descent, there is limited research on prostate cancer in Nigeria. Evidence-based medicine is a key tool in making clinical decisions and developing screening and treatment guidelines. This review was undertaken to assess the levels of evidence on prostate cancer research in Nigeria. A systematic review of all research published on prostate cancer from January 1975 to May 2018 in Nigeria was conducted. We reviewed all articles found on various databases by searching for “Prostate cancer in Nigeria”. We classified them based on their study designs into different levels of evidence as well as the year of publication. Meta-analyses were not considered in the review. A total of 171 articles were eligible for this review. Most publications were at the 4th(66%) and 5thlevels of evidence (17%) respectively. No clinical trials on prostate cancer in Nigeria was seen or registered on clinicaltrials.gov, hence no studies at level 1 (a, b or c) of evidence published in Nigeria. The commonest type of study design was cross-sectional studies accounting for 56% of all publications.Prostate cancer research is currently at low levels of evidence in Nigeria. It is pertinent to explore and increase funding channels for cancer-related research.