Prostate cancer is a leading cause of morbidity and mortality among men, especially of African descent. Over the years, there has been relative paucity of research work on the subject of prostate cancer in sub-Saharan Africa. The objective of the study is to examine records of prostate cancers diagnosed at Mayo Height laboratory, Lagos State University Teaching Hospital, Lagos, Nigeria between January 2015 and June 2018, with a view to studying the epidemiological variables and pattern seen. Histopathological slides were retrieved and reviewed; relevant data were extracted from the Laboratory Information Systems, Laboratory Requisition Forms and the Hospital records where necessary. The data were statistically analysed. A total of 333 cases of prostate cancer were diagnosed during the study period, representing 46.4% of all prostate specimens received. The median age of the patients at diagnosis was 70 years, with the lowest recorded age being 50 years, while the highest age was 90 years. Individuals in the 7th decade of life (61-70 years) were the most commonly affected. Overwhelming number of cases (97.3%) were diagnosed based on trucut biopsy specimens, compared to open prostatectomy specimen. Majority of the cancers were histologically adenocarcinomas (97.3%) and majority of the tumours were of high grade (Gleason grade 5) representing 37.5%. Prostate cancer is an obvious scourge in Nigeria. It is commonly seen in the 7th decade of life. Majority of the patients had high grade adenocarcinoma.