To examine how perceived behavioral control (PBC) is affected by sociodemographic and behavioral factors, employing a socio-ecologic approach, and identify the relative importance of these factors. This was a cross-sectional, correlational study of 500 Black men from the Prostate Cancer Transatlantic Consortium (CaPTC) familial project. A survey using standardized CaPTC measures collected information on intrapersonal (e.g., age, knowledge), interpersonal (e.g., cues to action, social support), and institutional factors (e.g., informed decision) that are predictive of perceived behavioral control. Black male participants, aged between 35-70 years, were recruited from the US, Nigeria, and Cameroon. Descriptive statistics (mean, SD, and frequency) were calculated for all variables, and multiple regression was employed to determine significant (p<0.05) predictors of PBC. Data were analyzed using SPSS v24. Participants had an average age of 48±10 years, low level of knowledge (mean=10.31±3.66; range 0-20), encountered very low cues to action (mean=1.60±2.13; range 0-13), had usual levels of social support (2.41±1.24), and were mostly (96.4%) not counseled on the advantages and disadvantages of prostate cancer screening. Attitude, knowledge, informed decision, and prostate cancer information seeking behavior were significant predictors, and the overall model accounted for 49% (p < 0.01) of the variation in PBC. Using a socio-ecologic approach, multi-level factors were integrated to facilitate a fuller understanding of the several factors impacting PBC in Black men. The four significant factors (attitude, knowledge, informed decision, and prostate cancer information seeking behavior knowledge) could be considered when developing culturally-sensitive interventions aimed at engaging at-risk Black men regarding prostate cancer prevention and early detection practices.